| 货号 | 5848/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1125.33 |
| 分子式 | C50H88N14O15 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | EPVDALGKAKV (Modifications: Val-11 = C-terminal amide) |
| 参考文献 | Ranayhossainiet al (2013) Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J.Biol.Chem. 288 36437. PMID: 24187133. |