L189 (10 MG)
货号：
3561/10 基本售价：
2369.5 元 规格：
10 mg
产品信息
概述| 货号 | 3561/10 |
| 别名 | 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone |
性能| 供应商 | Tocris |
| 生物活性 | DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 246.29 |
| 分子式 | C11H10N4OS |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 64232-83-3 |
| 参考文献 | Chenet al (2008) Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68 3169. PMID: 18451142. |
