| 货号 | 5830/1 |
| 供应商 | Tocris |
| 生物活性 | High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 902.13 |
| 分子式 | C51H67N9O6 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | KXFWLL (Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide) |
| 参考文献 | M'Kadmiet al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021. PMID: 26363071. Elset al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437. PMID: 22920150. |