| 货号 | 3592/10 |
| 供应商 | Tocris |
| 生物活性 | Synthetic gonadotropin-releasing hormone (GnRH) analog that behaves as an agonist at the GnRH receptors. Stimulates gonadotropin and sex hormone release in the short term, and causes suppression with continued administration. Displays antiproliferative activity in breast, prostate and endometrial cancers. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1269.42 |
| 分子式 | C59H84N18O14 |
| 可溶性/溶解性 | Soluble in water |
| CAS号 | 145781-92-6 |
| 序列号 | HWSYSLRP (Modifications: X = Pyr, Ser-4 = t-Bu-Ser, Pro-9 = terminal NH-NH-CO-NH2) |
| 参考文献 | Chatzakiet al (1996) The expression of gonadotropin-releasing hormone and its receptor in endometrial cancer, and its relevance as an autocrine growth factor. Cancer Res. 56 2059. PMID: 8616851. Dondiet al (1994) Antiproliferative effects of luteinizing hormone-releasing hormone (LHRH) agonists on human androgen-independent prostate cancer cell line DU 145: evidence for an autocrine-inhibitory LHRH loop. Cancer Res. 54 4091. PMID: 8033142. Chrisp and Goa (1991) Goserelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex-hormone-related conditions. Drugs 2254. |