| 货号 | 3910/1 |
| 供应商 | Tocris |
| 生物活性 | Selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1(KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50>100μM for α1β1,α5β1andα6β1). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 708.8 |
| 分子式 | C36H48N6O9 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in 0.2M PBS |
| CAS号 | 187735-94-0 |
| 序列号 | MPUPA-LDVP |
| 参考文献 | Muroet al (2009) Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 52 7974. PMID: 19891440. Chenet al (1999) Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 274 13167. PMID: 10224072. Linet al (1999) Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 42 920. PMID: 10072689. |