| 货号 | 0876/10 |
| 别名 | 1-(4-Methanesulfonamidophenoxy)-3-( |
| 供应商 | Tocris |
| 生物活性 | A specific blocker of the time dependent delayed rectifier potassium current, devoid of any β-adrenoceptor blocking activity. Exhibits proarrhythmic and prohypertensive activity in vivo. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 483.84 |
| 分子式 | C19H24Cl2N2O4S.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| CAS号 | 178894-81-0 |
| 参考文献 | Palenet al (2005) Role of SHP-1, Kv1.2 and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells. Cardiovasc.Res. 68 268. PMID: 15967421. Lei and Brown (1998) Inhibition by compound II, a sotalol analogue, of delayed rectifier current (iK) in rabbit sino-atrial node cells. Naunyn Schmiedebergs Arch.Pharmacol. 357 260. PMID: 9550297. Hagertyet al (1996) The in vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016. J.Pharm.Pharmacol. 48 417. PMID: 8794994. Connerset al (1992) Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. Br.J.Pharmacol. 106 958. PMID: 1393293. |