| 货号 | 1080/10 |
| 别名 | (2R)-(+)-8-Hydroxy-2-(di-n-propylam |
| 供应商 | Tocris |
| 生物活性 | Full 5-HT1A serotonin receptor agonist; more active enantiomer. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529). 7-Hydroxy-DPAT hydrobromide (Cat. No. 0706) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 328.29 |
| 分子式 | C16H25NO.HBr |
| 可溶性/溶解性 | Soluble to 75 mM in water and to 75 mM in DMSO |
| CAS号 | 80300-09-0 |
| 参考文献 | Yoshitake and Kehr (2004) Differential effects of (R)-, (R,S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865. PMID: 15050424. Corrfieldet al (1991) Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol.Pharmacol. 39 780. PMID: 1828859. Bjorket al (1989) Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain. J.Med.Chem. 32 779. PMID: 2522991. |