| 货号 | 1615/10 |
| 别名 | 4'-Chloro-3-methoxycinnamanilide |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB1 and CB2 receptors, voltage-gated Ca2+ channels and the hyperpolarization-activated current (Ih). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 287.75 |
| 分子式 | C16H14ClNO2 |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 472981-92-3 |
| 参考文献 | Gavvaet al (2005) Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol.Pharmacol. 68 1524. PMID: 16135784. Gunthorpeet al (2004) Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 46 133. PMID: 14654105. Fowleret al (2003) Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem.Pharmacol. 66 757. PMID: 12948856. |