| 货号 | 3873/10 |
| 别名 | (2'Z,3'E)-6-Bromo-1-methylindirubin-3 |
| 供应商 | Tocris |
| 生物活性 | Control analog of 6-bromoindirubin-3'-oxime (BIO, Cat. No. 3194). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC50 values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 370.2 |
| 分子式 | C17H12BrN3O2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 667463-95-8 |
| 参考文献 | Knockaertet al (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23 4400. PMID: 15077192. Polychronopouloset al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195. Meijeret al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633. |