| 货号 | 4795/10 |
| 别名 | 3,8,9,10-Tetrahydroxypyrano[3,2-c][ |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate). Inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells; thought to decrease cell viability via impairment of aerobic glycolysis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 316.26 |
| 分子式 | C12H5O8K |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO |
| 参考文献 | Fiumeet al (2013) Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells. Biochem.Biophys.Res.Commun. 430 466. PMID: 23237800. Farabegoliet al (2012) Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur.J.Pharm.Sci. 47 729. PMID: 22954722. Manerbaet al (2012) Galloflavin (CAS 568-80-9): a novel inhibitor of lactate dehydrogenase. ChemMedChem 7 311. PMID: 22052811. |