| 货号 | 5901/702U |
| 别名 | 3',5'-Cyclic diadenylic acid sodium salt |
| 供应商 | Tocris |
| 生物活性 | Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also A2A inverse agonist. Selectively induces apoptosis of monocytes in human PBMC cultures and in NSG mice transplanted with human CD34+cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 702.38 |
| 分子式 | C20H22N10Na2 |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| 参考文献 | Tosoliniet al (2015) Human monocyte recognition of adenosine-based cyclic dinucleotides unveils the A2aGαs protein-coupled receptor tonic inhibition of mitochondrially induced cell death. Mol.Cell.Biol. 35 479. PMID: 25384972. Parvatiyaret al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155. PMID: 23142775. |