| 货号 | 21852-1mg |
| 描述 | MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC50 value of 4 nM.1 This inhibitor does not target the activities of other MMPs in vitro.2,3 MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization.4 Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.5,6 |
| 别名 | Matrix Metalloproteinase-8 Inhibitor I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Matter, H.,Schudok, M.,Schwab, W., et al. Tetrahydroisoquinoline-3-carboxylate based matrix-metalloproteinase inhibitors: Design, synthesis and structure-activity relationship. Bioorg. Med. Chem. 10(11), 3529-3544 (2002). 2.McNulty, A.L.,Weinberg, J.B., and Guilak, F. Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus. Clin. Orthop. Relat. Res. 467(6), 1557-1567 (2009). 3.Prager, G.W.,Breuss, J.M.,Steurer, S., et al. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood 103(3), 955-962 (2004). 4.Chen, Q.,Jin, M.,Yang, F., et al. Matrix metalloproteinases: Inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators Inflamm. 928315 (2013). 5.Decock, J.,Hendricks, W.,Thirkettle, S., et al. Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice. Breast Cancer Res. 17:38, (2015). 6.Sarper, M.,Allen, M.D.,Gomm, J., et al. Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function. Breast Cancer Res. 19(1), 33 (2017). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 362.4 |
| 分子式 | C17H18N2O5S |
| CAS号 | 236403-25-1 |
| 稳定性 | ≥ 2 years |
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