| 货号 | 19572-1mg |
| 描述 | Hyperforin is a natural activator of the steroid X receptor (active at 0.1 to 0.5 µg/ml) and inhibitor of several cytochrome P450 (CYP) isoforms (IC50 = 10 µg/ml for CYP2D6).1,2 It can also inhibit microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50 = 1 µM), 5-lipoxygenase activating protein, and sirtuins.3,4,5 |
| 别名 | Hyp-DCHA;Hyperforin-DCHA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wentworth, J.M.,Agostini, M.,Love, J., et al. St. John’s wort, a herbal antidepressant, activates the steroid X receptor. Journal of Endocrinology 166, R11-R16 (2000). 2.Obach, R.S. Inhibition of human cytochrome P450 enzymes by constituents of St. John’s wort, an herbal preparation used in the treatment of depression. Journal of Pharmacology and Experimental Therapeutics 294(1), 88-95 (2000). 3.Chang, H.H., and Meuillet, E.J. Identification and development of mPGES-1 inhibitors: Where we are at? Future Med.Chem. 3(15), 1909-1934 (2011). 4.Greiner, C.,Hörnig, C.,Rossi, A., et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52) - a novel type 5-lipoxygenase inhibitor with favorable molecular pharmacology and efficacy in vivo. British Journal of Pharmacology 164(2b), 781-793 (2011). 5.Milne, J.C., and Denu, J.M. The sirtuin family:Therapeutic targets to treat diseases of aging. Current Opinion in Chemical Biology 12, 11-17 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 718.1 |
| 分子式 | C35H52O4 • C12H23N |
| CAS号 | 238074-03-8 |
| 稳定性 | ≥ 2 years |
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