| 货号 | 16958-250mg |
| 描述 | MPP+ is an active metabolite of MPTP (Item No. 16377), a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism.1,2,3,4MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress.5 The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.5 |
| 别名 | N-Methyl-4-Phenylpyridinium Iodide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burns, R.S.,Chiueh, C.C.,Markey, S.P., et al. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proceedings of the National Academy of Sciences of the United States of America 80(14), 4546-4550 (1983). 2.Fritz, R.R.,Abell, C.W.,Patel, N.T., et al. Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B. FEBS Letters 186(2), 224-228 (1985). 3.Javitch, J.A.,DAmato, R.J.,Strittmatter, S.M., et al. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings of the National Academy of Sciences of the United States of America 82(7), 2173-2177 (1985). 4.Goshima, Y.,Misu, Y.,Arai, N., et al. Nanomolar L-dopa facilitates release of dopamine via presynaptic β-adrenoceptors: Comparative studies on the actions in striatal slices from control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mice, an animal model for Parkinson’s disease. Japanese Journal of Pharmacology 55(1), 93-100 (1991). 5.Tieu, K. A guide to neurotoxic animal models of Parkinson’s disease. Cold Spring Harb.Perspect.Med. 1(1), (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.1 |
| 分子式 | C12H12N • I |
| CAS号 | 36913-39-0 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |