| 货号 | 14062-25mg |
| 描述 | Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM).12 Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands.345 In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.67 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Macia, E.,Ehrlich, M.,Massol, R., et al. Dynasore, a cell-permeable inhibitor of dynamin. Developmental Cell 10(6), 839-850 (2006). 2.Kirchhausen, T.,Macia, E. and Pelish, H.E. Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods in Enzymology 438, 77-93 (2008). 3.Chen, C.L.,Hou, W.H.,Liu, I.H., et al. Inhibitors of clathrin-dependent endocytosis enhance TGFβ signaling and responses. Journal of Cell Science 122, 1863-1871 (2009). 4.Barrias, E.S.,Reignault, L.C.,de Souza, W., et al. Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages. PLoS One 5(1), (2010). 5.de la Vega, M.,Marin, M.,Kondo, N., et al. Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but not complete fusion. Retrovirology 8(99), (2011). 6.Douthitt, H.L.,Luo, F.,McCann, S.D., et al. Dynasore, an inhibitor of dynamin, increases the probability of transmitter release. Neuroscience 172, 187-195 (2011). 7.Seil, M.,El Ouaaliti, M. and Dehaye, J.P. Secretion of IL-1β triggered by dynasore in murine peritoneal macrophages. Innate Immun. 18(2), 241-249 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 322.3 |
| 分子式 | C18H14N2O4 |
| CAS号 | 304448-55-3 |
| 稳定性 | ≥ 2 years |
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