13,14-dihydro Prostaglandin E1-d4
货号：
9000281-50ug 基本售价：
2240.0 元 规格：
50 ug
产品信息
概述| 货号 | 9000281-50ug |
| 描述 | 13,14-dihydro Prostaglandin E1-d4 (13,14-dh PGE1-d4) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of 13,14-dh PGE1 by GC- or LC-mass spectrometry. 13,14-dh PGE1 is an inhibitor of ADP-induced platelet aggregation in human platelet-rich plasma and washed platelets with IC50 values of 31 and 21 nM, respectively.1 13,14-dh PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 of 40 nM.2 Also, 13,14-dh PGE1 activates adenylate cyclase in NCB-20 hybrid cells with a Kact of 668 nM.3 |
| 别名 | 13,14-dh PGE1-d4;Prostaglandin E0-D4; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kobzar, G.,Mardla, V.,Järving, I., et al. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets. Comparative Biochemistry and Physiology 106(2), 489-494 (1993).
2.Kobzar, G.,Mardla, V.,Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proceedings of the Estonian Academy of Sciences.Chemistry 40, 179-180 (1991).
3.Blair, I.A.,Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. British Journal of Pharmacology 69, 519-525 (1980).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d4) |
| 计算分子量 | 360.5 |
| 分子式 | C20H32D4O5 |
| 稳定性 | ≥ 1 year |
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