| 货号 | 14903-1mg |
| 描述 | Manoalide is a natural sesterterpenoid which irreversibly inhibits secretory phospholipase A2 isoforms from human synovium, bee venom, and cobra venom (IC50 values are 3.9, 7.5, and 2 μM, respectively).1,2 It also potently blocks calcium channels (IC50 = 1 μM) and inhibits phospholipase C (IC50 = 1.5 μM).3,4,5 Manoalide can be used in biochemical, cellular, and in vivoexperiments.6,7,8 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Randazzo, A.,Debitus, C.,Minale, L., et al. Petrosaspongiolides M-R: New potent and selective phospholipase A2 inhibitors from the new caledonian marine sponge Petrosaspongia nigra. Journal of Natural Products 61(5), 571-575 (1998). 2.De Rosa, M.,Giordano, S.,Scettri, A., et al. Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues. Journal of Medicinal Chemistry 41(17), 3232-3238 (1998). 3.Wheeler, L.A.,Sachs, G.,De Vries, G., et al. Manoalide, a natural sesterterpenoid that inhibits calcium channels. The Journal of Biological Chemisty 262(14), 6531-6538 (1987). 4.Muallem, S.,Loessberg, P.,Sachs, G., et al. Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca2+-releasing mechanisms revealed by manoalide and benzohydroquinone. Biochemistry Journal 279(2), 367-375 (2013). 5.Bennett, C.F.,Mong, S.,Wu, H.L., et al. Inhibition of phosphoinositide-specific phospholipase C by manoalide. Molecular Pharmacology 32(5), 587-593 (1987). 6.Jacobson, P.B.,Marshall, L.A.,Sung, A., et al. Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide. Biochemical Pharmacology 39, 1557-1564 (1990). 7.Lister, M.D.,Glaser, K.B.,Ulevitch, R.J., et al. Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of monoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. The Journal of Biological Chemisty 264, 8520-8528 (1989). 8.Payá, M.,Terencio, M.C.,Ferrándiz, M.L., et al. Involvement of secretory phospholipase A2 activity in the zymosan rat air pouch model of inflammation. British Journal of Pharmacology 117, 1773-1779 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.6 |
| 分子式 | C25H36O5 |
| CAS号 | 75088-80-1 |
| 稳定性 | ≥ 6 months |
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