VU 0409106 (10 MG)
货号：
5322/10 基本售价：
2220.8 元 规格：
10 mg
产品信息
概述| 货号 | 5322/10 |
| 别名 | 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective mGlu5 negative allosteric modulator (IC50 = 49 nM at human mGlu5). Selective for mGlu5 over a panel of GPCRs and ion channels. Exhibits no significant nonspecific binding in rat brain homogenates in vitro. Inhibits marble burying behavior in mice. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 330.34 |
| 分子式 | C15H11FN4O2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Feltset al (2013) Discovery of VU0409106: A negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg.Med.Chem.Lett. 23 5779. PMID: 24074843. |
