| 货号 | 1567/1 |
| 别名 | N-(4,5-Dihydro-4-methyl-5-oxo-1,2-d |
| 供应商 | Tocris |
| 生物活性 | Antibiotic; inhibits bacterial RNA polymerase. Inhibits adhesion of HUVEC cells to vitronectin (IC50 = 0.83 mM) and subsequently reduces paxillin levels. Suppresses tumor cell-induced angiogenesis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 228.28 |
| 分子式 | C8H8N2O2S2 |
| 可溶性/溶解性 | Soluble to 5 mg/ml in DMSO |
| CAS号 | 87-11-6 |
| 参考文献 | Minamiguchiet al (2001) Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int.J.Cancer 93 307. PMID: 11433393. O'Neillet al (2000) RNA polymerase inhibitors with activity against rifampin-resistant mutants of Staphylococcus aureus. Antimicrob.Agents Chemother. 44 3163. PMID: 11036042. Jimenezet al (1973) Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob.Agents Chemother. 3 729. PMID: 4597739. |