| 货号 | 5594/1 |
| 供应商 | Tocris |
| 生物活性 | Potent TREK-1 channel blocker (IC50 = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2012.34 |
| 分子式 | C96H142N26O2 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | YAPLPRWSGPIGVSWGLR |
| 参考文献 | Borsottoet al (2015) Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br.J.Pharmacol. 172 771. PMID: 25263033. Mazellaet al (2010) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 8 e1000355. PMID: 20405001. |