| 货号 | 4023/100U |
| 供应商 | Tocris |
| 生物活性 | Selective NaV1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3826.59 |
| 分子式 | C168H250N46O |
| 可溶性/溶解性 | Soluble to 0.10 mg/ml in 4:1 Acetonitrile : water |
| 序列号 | YCQKWMWTCDSERKCCEGMVCRLWCKKKLW (Modifications: Disulfide bridge: 2-16, 9-21, 15-25) |
| 参考文献 | Edgertonet al (2008) Evidence for multiple effects of ProTxII on activation gating in NaV 1.5. Toxicon. 52 489. PMID: 18657562. Schmalhoferet al (2008) ProTx-II, a selective inhibitor of NaV 1.7 sodium channels, blocks action potential propagation in nociceptors. Mol.Pharmacol. 74 1476. PMID: 18728100. Smithet al (2007) Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation. J.Biol.Chem. 282 12687. PMID: 17339321. |