| 货号 | 3236/100U |
| 供应商 | Tocris |
| 生物活性 | Potent and competitive pituitary adenylate cyclase-activating polypeptide receptor (PAC)1 antagonist (IC50 = 2 nM). Inhibits PACAP(1-27)-induced stimulation of adenylate cyclase (Ki = 1.5 nM). Antitumor activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4024.78 |
| 分子式 | C182H300N56O |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| 序列号 | FTDSYSRYRKQMAVKKYLAAVLGKRYKQRV (Modifications: Lys-33 = C-terminal amide) |
| 参考文献 | Kojroet al (2006) The neuropeptide PACAP promotes a-secretase pathway for processing Alzheimer amyloid precursor protein. FASEB J. 20 512. PMID: 16401644. Leytonet al (1998) PACAP(6-38) inhibits growth of prostate cancer cells. Cancer Lett. 125 131. PMID: 9566707. Robberechtet al (1992) Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist. Eur.J.Biochem. 207 239. PMID: 1321043. |