| 货号 | 4545/1 |
| 别名 | (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-m |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of cathepsins B and L; also thought to inhibit calpain. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with pepstatin A (Cat. No. 1190). Lysosome and cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 342.43 |
| 分子式 | C17H30N2O5 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Kimet al (2008) Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 4 659. PMID: 18424912. Satoet al (2007) Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 67 9677. PMID: 17942897. Tanadaet al (2005) Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 1 84. PMID: 16874052. Wilcox and Mason (1992) Inhibition of cysteine proteinases in lysosomes and whole cells. Biochem.J. 285 495. PMID: 1637341. |