| 货号 | 3665/10 |
| 别名 | 1-[[[3-(2-Aminoethyl)-1H-indol-5-yl |
| 供应商 | Tocris |
| 生物活性 | Brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 439.94 |
| 分子式 | C23H25N5O2.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 170912-52-4 |
| 参考文献 | Munoz-Islaset al (2006) Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilation via 5-HT1B rather than 5-HT1D receptors. Br.J.Pharmacol. 149 82. PMID: 16880765. Letienneet al (2005) Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J.Pharmacol.Exp.Ther. 315 849. PMID: 16027226. Letienneet al (2003) Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J.Pharmacol.Exp.Ther. 305 749. PMID: 12606602. |