| 货号 | 1560/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective μ opioid receptor antagonist (IC50 = 3.5 nM). Displays > 1200-fold selectivity over δ opioid and somatostatin receptors. Brain penetrant and active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1104.32 |
| 分子式 | C51H69N13O11S2 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 103429-32-9 |
| 序列号 | FCYWRTXT (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, X = Pen, Disulfide bridge between 2 - 7, Thr-8 = C-terminal amide) |
| 参考文献 | Abbruscatoet al (1997) Blood-brain barrier permeability and bioavailability of a highly potent and μ-selective opioid receptor antagonist, CTAP: comparison with morphine. J.Pharmacol.Exp.Ther. 280 402. PMID: 8996221. Krameret al (1989) Novel peptidic mu opioid antagonists: pharmacologic characterization in vitroandin vivo. J.Pharmacol.Exp.Ther. 249 544. PMID: 2566679. Peltonet al (1986) Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for μ opioid receptors. J.Med.Chem. 29 2370. PMID: 2878079. |