| 货号 | 0898/2 |
| 别名 | 14β-(p-Chlorocinnamoylamino)-7,8-dih |
| 供应商 | Tocris |
| 生物活性 | Systemically active, irreversible μ-opioid receptor antagonist (apparent Ki values are 0.7, 1.9 and 5.7 nM for mouse μ,δandκ receptors respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 601.11 |
| 分子式 | C29H29ClN2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Broadbearet al (2000) Methocinnamox is a potent, long-lasting, and selective antagonist of morphine-mediated antinociception in the mouse: comparison with clocinnamox, β-funaltrexamine, and β-chlornaltrexamine. J.Pharmacol.Exp.Ther. 294 933. PMID: 10945843. Zerniget al (1996) Mechanism of clocinnamox blockade of opioid receptors: evidence from in vitroandex vivo binding and behavioural assays. J.Pharmacol.Exp.Ther. 279 23. PMID: 8858971. Burkeet al (1994) Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice. J.Pharmacol.Exp.Ther. 271 715. PMID: 7965787. Acetoet al (1989) Very long-acting narcotic antagonists. The 14β-p-substituted cinnamoylaminomorphinones and their partial mu agonist codeinone relatives. Arzneimittelforschung 39 570. PMID: 2547389. |