| 货号 | 5900/730U |
| 别名 | 3',5'-Cyclic diguanylic acid sodium salt |
| 供应商 | Tocris |
| 生物活性 | Endogenous STING and DDX41 agonist; mediates DDX41-STING interaction. Activates STING-dependent IFN-β production in mouse and human cells. Also induces an antitumor response in a lung B16-10 melanoma mouse model, when administered intravenously within YSKO5-liposomes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 734.37 |
| 分子式 | C20H22N10Na2 |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| 参考文献 | Nakamuraet al (2015) Liposomes loaded with a STING pathway ligand, cyclic di-GMP, enhance cancer immunotherapy against metastatic melanoma. J.Control Release 216 149. PMID: 26282097. Parvatiyaret al (2012) The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. Nat.Immunol. 13 1155. PMID: 23142775. Burdetteet al (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515. PMID: 21947006. |