货号 | 1337/1 |
别名 | (R)-Adenosine, cyclic 3',5'-(hydrogenphosphorothioate) triethylammonium |
供应商 | Tocris |
生物活性 | Cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC50 = 11 - 16 μM) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases. Enantiomer cAMPS-Sp, triethylammonium salt (Cat. No. 1333) also available. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
纯度 | >98 % |
计算分子量 | 446.46 |
分子式 | C10H12N5O5PS.C6H15N |
可溶性/溶解性 | Soluble to 100 mM in water |
CAS号 | 73208-40-9 |
参考文献 | Ducaet al (2015) Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. Nat.Med. 21 506. PMID: 25849133. Fuet al (2008) PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol.Pain 4 26. PMID: 18631385. Kuriyamaet al (1995) Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest.Ophthalmol.Vis.Sci. 36 730. PMID: 7890503. Dostmannet al (1990) Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J.Biol.Chem. 265 10484. PMID: 2162349. Rothermel and Botelho (1988) A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem.J. 251 757. PMID: 2843164. Van Haastertet al (1984) Competitive cAMP antagonists for cAMP-receptor proteins. J.Biol.Chem. 259 10020. PMID: 6088478. |