| 货号 | 3604/1 |
| 别名 | (3S,5Z,8S,9S,11E)-3,4,9,10-tetrahyd |
| 供应商 | Tocris |
| 生物活性 | Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor-β-activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF-κB (IC50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 362.37 |
| 分子式 | C19H22O7 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 66018-38-0 |
| 参考文献 | Windheimet al (2007) Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem.J. 404 179. PMID: 17348859. Chooet al (2006) Blockade of transforming growth factor-β-activated kinase 1 activity enhances TRAIL-induced apoptosis through activation of a caspase cascade. Mol.Cancer Ther. 5 2970. PMID: 17172402. Ninomiya-Tsujiet al (2003) A resorcyclic acid lactone, 5Z-7-Oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J.Biol.Chem. 278 18485. PMID: 12624112. |