| 货号 | 4703/1 |
| 别名 | (1S,2R,5R)-5-(4-Amino-1H-imidazo[4, |
| 供应商 | Tocris |
| 生物活性 | Histone methyltransferase inhibitor; decreases global histone methylation. Inhibits EZH2 histone methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in vitro. Induces apoptosis in multiple cancer cell lines and has no apoptotic effect on normal cells. Enhances Oct4 expression in chemically induced pluripotent stem cells (CiPSCs). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 298.73 |
| 分子式 | C12H14N4O3 |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| 参考文献 | Houet al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. Science 341 651. PMID: 23868920. Mirandaet al (2009) DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol.Cancer Ther. 8 1579. PMID: 19509260. Tanet al (2007) Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21 1050. PMID: 17437993. Tsenget al (1989) Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities. J.Med.Chem. 32 1442. PMID: 2544721. |