| 货号 | 20001-1ea |
| 描述 | This mixture contains all of the primary cysteinyl-leukotrienes derived from arachidonic acid. Contents: Leukotriene C4, Leukotriene D4, Leukotriene E4, Leukotriene F4, and N-acetyl Leukotriene E4 (5 µg each). The leukotrienes are 5-lipoxygenase metabolites most commonly associated with asthma, where they are one of the causative agents in anaphylaxis and bronchoconstriction.1,2,3,4 This product contains the primary CysLT, LTC4, produced by the addition of glutathione to LTA4 by the MAPEG-group enzyme LTC4synthase.5 It also contains each of the sequential leukotriene metabolites, LTD4, LTE4, LTF4, and N-acetyl-LTE4. These metabolites span a very wide polarity range and separate well on reversed phase HPLC. |
| 别名 | CysLT HPLC Mixture I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dahlén, S.E.,Hansson, G.,Hedqvist, P., et al. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proceedings of the National Academy of Sciences of the United States of America 80, 1712-1716 (1983). 2.Levin, R.I.,Jaffe, E.A.,Weksler, B.B., et al. Nitroglycerin stimulates synthesis of prostacyclin by cultured human endothelial cells. Journal of Clinical Investigation 67, 762-769 (1981). 3.Murphy, R.C.,Hammarström, S. and Samuelsson, B. Leukotriene C: A slow-reacting substance from murine mastocytoma cells. Proceedings of the National Academy of Sciences of the United States of America 76, 4275-4279 (1979). 4.Samuelsson, B.,Dahlén, S.E.,Lindgren, J.Å., et al. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 237, 1171-1176 (1987). 5.Penrose, J.F. LTC4 synthase. Enzymology, biochemistry, and molecular characterization. Clinical Reviews in Allergy and Immunology 17, 133-152 (1999). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% for each compound |
| 稳定性 | ≥ 6 months |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |