| 货号 | 1151/200U |
| 别名 | Corticotropin-Releasing Factor (human, rat) |
| 供应商 | Tocris |
| 生物活性 | Endogenous peptide agonist for the CRF receptor (Ki values are 11, 44 and 38 nM for hCRF1, rCRF2a and mCRF2b respectively). Stimulates the synthesis and release of ACTH from the anterior pituitary. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4758 |
| 分子式 | C208H344N60O |
| 可溶性/溶解性 | Soluble to 1.10 mg/ml in water |
| 序列号 | SEEPPISLDLTFHLLREVLEMARAEQLAQQ (Modifications: Ile-41 = C-terminal amide) |
| 参考文献 | Perrinet al (1999) Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors. J.Pharmacol.Exp.Ther. 288 729. PMID: 9918582. Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. PMID: 10816663. Rivieret al (1986) Mediation by corticotropin releasing factor (CRF) of adenohypophysial hormone secretion. Annu.Rev.Physiol. 48 475. PMID: 2871808. Souzaet al (1984) Corticotropin-releasing factor receptors in rat forebrain: autoradiographic identification. Science 224 1449. PMID: 6328656. Tacheet al (1983) Inhibition of gastric acid secretion in rats by intracerebral injection of corticotropin-releasing factor. Science 222 935. PMID: 6415815. Valeet al (1981) Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and β-endorphin. Science 213 1394. PMID: 6267699. |