| 货号 | 16385-1mg |
| 描述 | α-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~ 2.5 µM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis.1,2,3 It has been widely used to characterize activity at the neuromuscular junction, which has numerous applications in neuroscience research.4,5 |
| 别名 | α-Bgt;α-BTX; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Changeux, J.P.,Kasai, M. and Lee, C.Y. Use of a snake venom toxin to characterize the cholinergic receptor protein. Proceedings of the National Academy of Sciences of the United States of America 67(3), 1241-1247 (1970). 2.Mukhin, A.G.,Gündisch, D.,Horti, A.G., et al. 5-Iodo-A-85380, an α4β2 subtype-selective ligand for nicotinic acetylcholine receptors. Molecular Pharmacology 57(3), 642-649 (2000). 3.Plomp, J.J. and Molenaar, P.C. Involvement of protein kinases in the upregulation of acetylcholine release at endplates of α-bungarotoxin-treated rats. Journal of Physiology 493, 175-186 (1996). 4.Grady, S.R.,Salminen, O.,Laverty, D.C., et al. The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum. Biochemical Pharmacology 74(8), 1235-1246 (2007). 5.Nirthanan, S. and Gwee, M.C.E. Three-finger α-neurotoxins and the nicotinic acetylcholine receptor, forty years on. Journal of Pharmacological Sciences 94(1), 1-17 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 7984.3 |
| 分子式 | C338H529N97O105S11 |
| CAS号 | 11032-79-4 |
| 稳定性 | ≥ 1 year |
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