| 货号 | 1800/1 |
| 别名 | Leukocyte chemoattractant peptide |
| 供应商 | Tocris |
| 生物活性 | Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Also promotes monocyte survival through a PKC-, PI 3-kinase- and Akt-dependent pathway. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 856.11 |
| 分子式 | C41H61N9O7S2 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in water |
| CAS号 | 187986-17-0 |
| 序列号 | WKYMVM (Modifications: Met-6 = D-Met & C-terminal amide) |
| 参考文献 | Baeet al (2002) The synthetic chemoattractant peptide, Trp-Lys-Tyr-Met-Val-D-Met, enhances monocyte survival via PKC-dependent Akt activation. J.Leukoc.Biol. 71 329. PMID: 11818455. Christopheet al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585. PMID: 11285256. Leet al (1999) Utilization of two seven-transmembrane, G protein-coupled receptors, formyl peptide receptor-like 1 and fomyl peptide receptor, by the synthetic hexapeptide WKYMVm for human phagocyte activation. J.Immunol. 163 6777. PMID: 10586077. |