| 货号 | 3916/10 |
| 别名 | 6-[(Aminocarbonyl)(2,6-difluorophen |
| 供应商 | Tocris |
| 生物活性 | Orally active, ATP-competitive inhibitor of p38α MAPK; also inhibits p38β (KD values are 3.7 and 17 nM respectively). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 404.32 |
| 分子式 | C19H12F4N4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 479543-46-9 |
| 参考文献 | Goldsteinet al (2010) Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J.Med.Chem. 53 2345. PMID: 19950901. Damjanovet al (2009) Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis. Arthrit.Rheumat. 601232. Din (2006) Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome. Curr.Opin.Investig.Drugs 7 1020. PMID: 17117592. |