| 货号 | 0807/50 |
| 别名 | 4,5,6,7-Tetrahydroisoxazolo[5,4-c]p |
| 供应商 | Tocris |
| 生物活性 | Systemically active GABAA receptor agonist and GABAA-ρ receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 176.6 |
| 分子式 | C6H8N2O2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 64603-91-4 |
| 参考文献 | Huckle (2004) Gaboxadol. Lundbeck/Merck Curr.Opin.Investig.Drugs 5 766. PMID: 15298075. Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697. Krogsgaard-Larson (1984) Chemistry and pharmacology of the GABA antagonists THIP (Gaboxadol) and isoguvacine. Drugs Future. 9597. Krogsgaard-Larson (1983) 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity. J.Med.Chem. 26 895. PMID: 6304315. |