| 货号 | 1784/1 |
| 别名 | [D-Arg1,D-Trp7,9,Leu11]-Substance P |
| 供应商 | Tocris |
| 生物活性 | Selective NK1 receptor antagonist (Ki values are 230, 8150 and > 10000 nM for rat NK1, NK2 and NK3 receptors respectively). Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1497.8 |
| 分子式 | C75H108N20O13 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 91224-37-2 |
| 序列号 | RPKPQQWFWLL (Modifications: Arg-1 = D-Arg, Trp-7 = Trp-9 = D-Trp) |
| 参考文献 | Zubrzyckaet al (2000) Comparison of antagonistic properties of substance P analogs, spantide I, II and III, on evoked tongue jerks in rats. Endocr.Regul. 34 13. PMID: 10808247. Beaujouanet al (1993) Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK1 antagonists. Br.J.Pharmacol. 108 793. PMID: 7682138. Folkerset al (1984) Biological evaluation of substance P antagonists. Br.J.Pharmacol. 83 449. PMID: 6207886. |