| 货号 | 0756/50 |
| 别名 | Amino-3-morpholinyl-1,2,3-oxadiazol |
| 供应商 | Tocris |
| 生物活性 | This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 206.63 |
| 分子式 | C6H11ClN4O2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 16142-27-1 |
| 参考文献 | Siegfriedet al (1992) Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ichemia-reperfusion. J.Pharmacol.Exp.Ther. 260 668. PMID: 1738117. Maurice and Heslam (1990) Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol.Pharmacol. 37 671. PMID: 2160060. Nishikawaet al (1982) Inhibition of platelet aggregation and stimulation of guanylate cyclase by an anti-anginal agent molsidomine and its metabolite. J.Pharmacol.Exp.Ther. 220 183. PMID: 6118429. Tanayamaet al (1974) Biotransformation of molsidomine (SIN-10), a new anti-anginal agent in rats. Xenobiotica 4175. |