| 货号 | 4440/50 |
| 别名 | N-Ethyl-N-methylcarbamic acid 3-[(1S)-1-(dimethylamino)ethyl]phen |
| 供应商 | Tocris |
| 生物活性 | Dual cholinesterase inhibitor (ChEI); inhibits both butyrylcholinesterase (BChE) and acetylcholinesterase (AChE). Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 400.42 |
| 分子式 | C14H22N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Mehtaet al (2012) New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis. PMID: 22216416. Baileyet al (2011) Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 6 e21954. PMID: 21799757. Groneret al (2007) The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 71 1610. PMID: 17347320. Luoet al (2006) Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 49 2174. PMID: 16570913. |