| 货号 | 2296/10 |
| 别名 | (5Z,11α,13E,15S)-11,15-Dihydroxy-9-o |
| 供应商 | Tocris |
| 生物活性 | Endogenous prostaglandin and primary product of arachidonic acid/cyclooxygenase pathway. Binds with high affinity to EP1, EP2, EP3 and EP4 receptors (Kd values range between ~ 1 - 10 nM). Influences a wide range of processes including inflammation, smooth muscle relaxation, fertility and gastric mucosal integrity. Regulates vertebrate hematopoietic stem cell (HSC) homeostasis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 352.47 |
| 分子式 | C20H32O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 45 mM in ethanol |
| CAS号 | 363-24-6 |
| 参考文献 | Northet al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447 1007. PMID: 17581586. Hata and Breyer (2004) Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharm.Ther. 103147. Colemanet al (1994) Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol.Rev. 46 205. PMID: 7938166. |