| 货号 | 3140/10 |
| 别名 | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)- |
| 供应商 | Tocris |
| 生物活性 | Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC50 ~ 0.86 - 5.87 μM) and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2) (IC50 = 171 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 249.7 |
| 分子式 | C12H11N3O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 845714-00-3 |
| 参考文献 | Jackson (2008) Stopping replication, at the beginning. Nature Chem.Biol. 4331. Montagnoliet al (2008) A cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumour activity. Nature Chem.Biol. 4357. Andersonet al (2007) Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). J.Med.Chem. 50 2647. PMID: 17480064. |