| 货号 | 2613/50 |
| 别名 | 8-Hydroxy-7-[(6-sulfo-2-naphthyl)az |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 459.45 |
| 分子式 | C19H13N3O7S2 |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 20 mM in DMSO |
| CAS号 | 56990-57-9 |
| 参考文献 | Redondeet al (2007) hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J.Thromb.Haemost. 5 2476. PMID: 17892531. Zhaoet al (2007) Regulation of ACh receptor clustering by the tyrosine phosphatase Shp2. Dev.Neurobiol. 67 1789. PMID: 17659592. Chenet al (2006) Discovery of a novel shp2 protein tyrosine phosphatase inhibitor. Mol.Pharmacol. 70 562. PMID: 16717135. |