| 货号 | 3615/1 |
| 供应商 | Tocris |
| 生物活性 | Angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 795.98 |
| 分子式 | C39H61N11O7 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 358738-77-9 |
| 序列号 | RPLKPW |
| 参考文献 | Ohinataet al (2009) Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice. Peptides 30 1105. PMID: 19463743. Yamadaet al (2008) A potent hypotensive peptide, novokinin, induces relaxation by AT2- and IP-receptor-dependent mechanism in the mesenteric artery from SHRs. Biosci.Biotechnol.Biochem. 72 257. PMID: 18175894. Yamadaet al (2008) Hypotensive activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by angiotensin AT2 receptor and prostaglandin IP receptor. Peptides 29 412. PMID: 18207609. |