| 货号 | 4640/10 |
| 别名 | (2S,3R,4E)-2-(Dimethylamino)-4-octa |
| 供应商 | Tocris |
| 生物活性 | Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation; does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1β and MCP-1 in cultured astrocytes; thought to mediate mechanical allodynia via this mechanism. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 327.55 |
| 分子式 | C20H41NO2 |
| 可溶性/溶解性 | Soluble to 30 mM in DMSO |
| 参考文献 | Pattiet al (2012) Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin. Nat.Chem.Biol. 8 232. PMID: 22267119. Edsallet al(1998)N,N-dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37 12892. PMID: 9737868. Yatomiet al(1996)N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35 626. PMID: 8555236. |