| 货号 | 3908/50 |
| 别名 | (±)-N-[4-[4-(Ethylheptylamino)-1-hyd |
| 供应商 | Tocris |
| 生物活性 | Class III antiarrhythmic. Blocks the rapid component of delayed rectifier K+ current (IKr); also blocks hERG channels and L-type Ca2+ channels. Shown to activate a slow inward Na+ current in guinea pig ventricular cells. Used to terminate atrial fibrillation and atrial flutter; can prolong QT. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 442.61 |
| 分子式 | C20H36N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in water |
| 参考文献 | Perryet al (2004) Structural determinants of HERG channel block by clofilium and ibutilide. Mol.Pharmacol. 66 240. PMID: 15266014. Lee and Lee (1998) Ionic mechanism of ibutilide in human atrium: evidence for a drug-induced Na+ current through nifedipine inhibited inward channel. J.Pharmacol.Exp.Ther. 286 9. PMID: 9655836. Murray (1998) Ibutilide. Circulation 97 493. PMID: 9490245. Merck Index 124927. |