| 货号 | 2645/10 |
| 别名 | 2-[3-[4-(4-Fluorophenyl)-1-piperazi |
| 供应商 | Tocris |
| 生物活性 | 5-HT2A receptor antagonist that also displays high affinity at D4 receptors (Ki values are 0.26, 2.93, 25, 38, 70 and 726 nM for 5-HT2A, D4, H1,α1, 5-HT1A and D2 receptors respectively). Inhibits inositol phosphate formation evoked by 5-HT in vitro(IC50 = 7.76 nM) and antagonizes mescaline-induced head twitches in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 425.52 |
| 分子式 | C23H24FN3O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 127625-29-0 |
| 参考文献 | Heuilletet al (1996) The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor. Eur.J.Pharmacol. 314 229. PMID: 8957240. Dobleet al (1992) Pharmacological characterization of RP 62203, a novel 5-hydroxytryptamine 5-HT2 receptor antagonist. Br.J.Pharmacol. 105 27. PMID: 1596688. Malleronet al (1991) Naphthosultam derivatives: a new class of potent and selective 5-HT2 antagonists. J.Med.Chem. 34 2477. PMID: 1908521. |