| 货号 | 2409/50 |
| 别名 | N,N-Dimethyl-con-5-enin-3-amine |
| 供应商 | Tocris |
| 生物活性 | Potent and selective histamine H3 receptor antagonist (pKi values are 7.61 and 8.27 at rat and human H3 receptors respectively). A steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Also has high affinity for α2C adrenoceptors (pKi = 7.98). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 356.59 |
| 分子式 | C24H40N2 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 50 mM in DMSO with gentle warming |
| CAS号 | 546-06-5 |
| 参考文献 | Zhaoet al (2008) The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J.Med.Chem. 51 5423. PMID: 18683917. Witteet al (2005) Discovery of a novel natural product of unique chemical structure as a potent and selective histamine H3 receptor (H3R) antagonist. Soc.Neurosci.Abstr. 49119. Zirihiet al (2005) Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg.Med.Chem.Lett. 15 2637. PMID: 15863333. |