| 货号 | 4246/10 |
| 别名 | 1-[3,5-Bis(1,1-dimethylethyl)-4-hyd |
| 供应商 | Tocris |
| 生物活性 | Selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway (IC50 < 0.1 μM for PMA-stimulated IL-8 production). Inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Does not inhibit other NF-κB pathways, including that activated by tumor necrosis factor (TNF). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 465.63 |
| 分子式 | C28H39N3O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Peddibhotlaet al (2010) Inhibition of protein kinase C-driven NF-κB activation: synthesis, SAR, and pharmacological profiling of pathway specific benzimidazole probe molecules. J.Med.Chem. 53 4793. PMID: 20481485. Shiet al (2010) Chemical biology strategy reveals pathway-selective inhibitor of NF-κB activation induced by protein kinase C and antigen receptors. ACS Chem.Bio. 5287. |