| 货号 | 1330/5 |
| 别名 | 1,2-Dimethoxy-12-methyl[1,3]benzodi |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 383.83 |
| 分子式 | C21H18ClNO4 |
| 可溶性/溶解性 | Soluble to 10 mM in water and to 10 mM in DMSO |
| CAS号 | 34316-15-9 |
| 参考文献 | Chanet al (2003) Identification of chelerythrine as an inhibitor of BclXL function. J.Biol.Chem. 278 20453. PMID: 12702731. Yuet al (2000) Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C. J.Biol.Chem. 275 9612. PMID: 10734112. Leeet al (1998) Angoline and chelerythrine, benzophenanthridine alkaloids that do not inhibit protein kinase C. J.Biol.Chem. 273 19829. PMID: 9677417. Herbertet al (1990) Chelerythrine is a potent and specfic inhibitor of protein kinase C. Biochem.Biophys.Res.Commun. 172 993. PMID: 2244923. |