| 货号 | 4863/1 |
| 别名 | N-[[(2S,3S)-3-[(Propylamino)carbony |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of cathepsin B (Ki = 2-5 nM). Displays selectivity over cathepsins H and L (Ki = 40-200 μM). Shown to reduce bone metastasis in a 4T1.2 breast cancer model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 383.44 |
| 分子式 | C18H29N3O6 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 20 mM in ethanol |
| 参考文献 | Withanaet al (2012) Cathepsin B inhibition limits bone metastasis in breast cancer. Cancer Res. 72 1199. PMID: 22266111. Gilletet al (2009) Voltage-gated sodium channel activity promotes cysteine cathepsin-dependent invasiveness and colony growth of human cancer cells. J.Biol.Chem. 284 8680. PMID: 19176528. Towatariet al (1991) Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 280 311. PMID: 2013329. |